De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures

By Bobo Dang, Haifan Wu, Vikram Khipple Mulligan, M. Mravic, Yibing Wu, Thomas Lemmin, Alex Ford, Daniel‐Adriano Silva, David Baker, William F. DeGrado. 2017

48 citations recorded by the source corpus.

Subfields: Molecular Biology

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In Molecular Biology

Citations in the corpus

Designing Peptides on a Quantum Computer (2019, methodology): “More recently, Rosetta has been generalized to allow the design of diverse synthetic heteropolymers that fold as proteins do, but which are built from moieties not used by natural proteins (non-canonical side-chains and backbone chemistries) ( 14 – 18 ) .”
A general-purpose protein design framework based on mining sequence–structure relationships in known protein structures (2018, unknown): “Nevertheless, despite all of these developments, and many examples of successful designs in the literature (18, 26-35), it is still the case that CPD methods are not robust.”
Reconfigurable asymmetric protein assemblies through implicit negative design (2021, unknown): “S1 to S14 Tables S1 to S4 References (34-55) Data S1_components_and_assemblies.”
Essentials of de novo protein design: Methods and applications (2018, background): “39,40,68 For designing β -bulges in globular proteins (irregularities in the backbone of β -strands that enhance β -sheet curvature), the alternating polar/hydrophobic side chain patterns that characterize uniform β -strands can be specifically biased in the β -bulge area.”
Recent advances in de novo protein design: Principles, methods, and applications (2021, methodology): “GenKIC was also applied to design meso-size proteins stabilized by multivalent cross-linkers (80).”
De novo protein design, a retrospective (2020, unknown): “Moreover, repeat proteins (discussed below), mini-proteins, and cyclic peptides including ones with D-amino acids or unnatural crosslinks have been prepared and structurally verified (Bhardwaj et al., 2016; Chevalier et al., 2017; Dang et al., 2017; Marcos et al., 2018) (Fig.”