Statistical tests of selective neutrality in the age of genomics

By Rasmus Nielsen. Heredity, 2001

828 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/920caad5b65666908127736abee5f2a6d5f7f85e

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In Genetics

Citations in the corpus

Geographic Patterns of (Genetic, Morphologic, Linguistic) Variation: How Barriers Can Be Detected by Using Monmonier's Algorithm (2004, background): “There is an increasing interest in those statistical investigations focused towards the detection of selection processes across geographic space (Nielsen 2001) and the popularization of the Monmonier’s algorithm is likely to put forward the understanding of such phenomena.”
Beyond FST: Analysis of population genetic data for conservation (2004, methodology): “Considering single-locus sequence data, Nielsen (2001) pointed out that neutrality tests such as Tajima’s D-test (Tajima 1989) are actually unable to distinguish between the signal generated by selection on the locus and that of a past bottleneck in the population, and thus could function equally…”
PAML 4: phylogenetic analysis by maximum likelihood. (2007, methodology): “Branch-site model lysozyme Yang and Nielsen (2002) Messier and Stewart (1997)”
Interrogating a high-density SNP map for signatures of natural selection. (2002, background): “…2000), guide selection of loci for inclusion in population genetic studies (Vitalis et al. 2001), facilitate the annotation of functionally significant genomic regions (Nielsen 2001), and help elucidate genotype-phenotype correlations in complex diseases (Przeworski et al. 2000; Nielsen 2001).”
MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years? (2003, background): “Although apparently counterintuitive, this pattern is consistent with the model proposed by Nowak et al. (1992) according to which a high number of MHC alleles might not be an optimal solution for pathogen resistance.”