Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches
By Xi-Feng Zhang, Zhi-guo Liu, Wei Shen, Sangiliyandi Gurunathan. International Journal of Molecular Sciences, 2016
1,806 citations recorded by the source corpus.
Recent advances in nanoscience and nanotechnology radically changed the way we diagnose, treat, and prevent various diseases in all aspects of human life. Silver nanoparticles (AgNPs) are one of the most vital and fascinating nanomaterials among several metallic nanoparticles that are involved in biomedical applications. AgNPs play an important role in nanoscience and nanotechnology, particularly in nanomedicine. Although several noble metals have been used for various purposes, AgNPs have been focused on potential applications in cancer diagnosis and therapy. In this review, we discuss the synthesis of AgNPs using physical, chemical, and biological methods. We also discuss the properties of AgNPs and methods for their characterization. More importantly, we extensively discuss the multifunctional bio-applications of AgNPs; for example, as antibacterial, antifungal, antiviral, anti-inflammatory, anti-angiogenic, and anti-cancer agents, and the mechanism of the anti-cancer activity of AgNPs. In addition, we discuss therapeutic approaches and challenges for cancer therapy using AgNPs. Finally, we conclude by discussing the future perspective of AgNPs.
Subfields: Biomaterials, Biomedical Engineering, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/92075921a25a07035a0a8cc99f0a7de7b8083ff5
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Citations in the corpus
- Biosynthesis of Copper Oxide Nanoparticles Using Streptomyces MHM38 and Its Biological Applications (2021, background): “Metal nanoparticles are synthesized and used because of their unique electrical, optical, catalytic, and magnetic characteristics [1 – 3], which di ff er from the characteristics of bulk materials.”
- Silver Nanoparticles and Their Antibacterial Applications (2021, background): “Nevertheless, this is considered one of the most promising methods in view that it is low cos and there is a w variety of natural resources to be used at co tribu e to reducing the po ential toxicity of nan particles [24].”
- A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives (2017, neutral): “Ag-NPs exhibited increased toxicity under a hypoxic environment at exposure levels 3 and 50 m g/mL in A549 cells, normal lung epithelial cells (L132), human ovarian cancer cells (A2780), and human breast cancer cells (MCF-7 and MDA-MB 231) [103].”
- Biosynthesis of silver nanoparticles and their versatile antimicrobial properties (2018, methodology): “they have been used as antiviral (by the shipment ofHIV−1 in human cervix organ in culturemedia), antiinflammatory and anticancer agents [19, 20].”
- Metal-Based Nanoparticles as Antimicrobial Agents: An Overview (2020, background): “AgNPs demonstrated to be antiangiogenic and antiproliferative [59].”
- Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview (2018, background): “The impressive antimicrobial activity of AgNPs is a solid starting point for the design, development, and implementation of new and performance-enhanced nanosilver-based biomedical products, such as anticancer agents, drug-delivery platforms, orthopedic materials and devices [47], bandages, antisept”
- Silver Nanoparticles: Synthesis and Application for Nanomedicine (2019, background): “Efforts have been made to explore their attractive properties and utilize them in practical applications, such as anti-bacterial and anti-cancer therapeutics [9], diagnostics and optoelectronics [10–12], water disinfection [13], and other clinical/pharmaceutical applications [14].”