Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

By S. Neil, Trinity M Zang, P. Bieniasz. Nature, 2008

1,961 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/91e47cc935afd81137b74efca2f9bdd5b3855cd5

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In Virology

Citations in the corpus

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol (2012, background): “…a 3–5’ exonuclease, degrades single stranded viral RNA; PKR inhibits viral translation through suppression of eIF2a elongation factors and tetherin prevents release of virions from the cell (Degols et al., June; García et al., 2006; Neil et al., 2008; Van Damme et al., 2008; Brass et al., 2009).”
Tetherin inhibits HIV-1 release by directly tethering virions to cells (2009, neutral): “Speciesspecific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2.”
Origins of HIV and the AIDS pandemic. (2011, background): “2004); and (3) tetherin (also termed BST-2 and CD317) which inhibits the budding and release of virions from infected cells (Neil et al. 2008).”
HIV-1 accessory proteins--ensuring viral survival in a hostile environment. (2008, background): “However, although overexpressed Vpu has been reported to reduce tetherin expression levels (Bartee et al., 2006), the physiological pertinence of this remains questionable since similar effects have not been observed in the context of HIV-1 infection (Neil et al., 2008).”
GUIDANCE: a web server for assessing alignment confidence scores (2010, background): “The protein contains (cid:2) 80 amino acids and has two known major functions, which are conducted by two distinct domains of the protein: (i) promotion of CD4 degradation via the cytoplasmic domain; and (ii) enhancement of virion release from host cells via the trans-membrane domain, which was impl”