Natural selection on protein-coding genes in the human genome

By Carlos D. Bustamante, A. Fledel-Alon, S. Williamson, Rasmus Nielsen, Melissa Hubisz, S. Glanowski, D. Tanenbaum, T. White, J. Sninsky, Ryan D. Hernandez and 4 more. Nature, 2005

803 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/91d363f28230e1cdc8c940f79f8cdb7356036cb5

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Citations in the corpus

Genomic Consequences of Outcrossing and Selfing in Plants (2008, background): “Keywords: inbreeding, genome evolution, recombination, transposable elements, genome size, deleterious mutation.”
Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome (2008, methodology): “Resequencing was performed by Celera Genomics using PCR amplification of over 20,362 putative genes from the 2001 human genome in 19 African Americans and 20 European Americans (see [40] for a detailed description of this sequencing).”
Comparative Genomics (2007, neutral): “As was the case for human-mouse comparisons discussed above, the KA/KS ratio was computed in genome-wide comparison of the human and chimpanzee gene sets (Clark et al. 2003; Bustamante et al. 2005; Chimpanzee Sequencing and Analysis Consortium 2005; Nielsen et al. 2005).”
Natural selection on genes that underlie human disease susceptibility. (2008, methodology): “, if the selection coefficients acting on homozygotes are often in the range 28 < Nes < 0, where Ne is the effective population size) [7, 11], genes in which mutations cause recessive disorders should have higher Dn/Ds values than do those in which mutations lead to dominant disorders (e.”
Searching for missing heritability: Designing rare variant association studies (2014, background): “The paper also raises a number of further research questions in human genetics, including improved ways to estimating s and α for each gene and analyzing gene sets comprised of genes with varying properties (60).”
Neutral and weakly nonneutral sequence variants may define individuality (2013, result): “This ﬁ nding is in line with the notion of variant purifying selection (28, 29).”
Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics (2014, background): “A consensus result is that the DFE is characteristically skewed and can be described by a gamma distribution [32,34,35].”
Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach (2007, background): “We note that positive selection is not a common phenomenon and is not apparent in most examined datasets (9, 10 ).”
THE LOCUS OF EVOLUTION: EVO DEVO AND THE GENETICS OF ADAPTATION (2007, background): “Those who feel otherwise would do well to remember Carl Sagan‘s (1987, p. 45) testy remark when pressed to give an opinion about the probability of extraterrestrial intelligence: “Really, it’s okay to reserve judgment until the evidence is in.””
Genetic Polymorphism in Heterogeneous Environments: The Age of Genomics (2006, background): “…the availability of multiple genome sequences for a number of organisms (particularly in humans), there has been an intensive search for genomic regions exhibiting a signal of adaptive (positive Darwinian) selection (Akey et al. 2004, Bustamante et al. 2005, Nielsen et al. 2005, Wang et al. 2006).”