Cubism and the cell cycle: the many faces of the APC/C

By J. Pines. Nature reviews. Molecular cell biology, 2011

286 citations recorded by the source corpus.

Subfields: Biophysics

View Paper: https://www.semanticscholar.org/paper/917e38b5a713f0b323607894c7036eed485f781f

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Citations in the corpus

• Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events (2014, background): “Satisfaction of the SAC removes its inhibitory pressure on the anaphase-promoting complex (APC), allowing the APC to target key mitotic substrates for degradation by the proteasome.(6,7) These substrates include securin, which, when degraded, allows separation of sister chromatids, and cyclin B1, wh”
• The spindle assembly checkpoint. (2012, background): “The downstream target of the SAC is the anaphase promoting complex, or cyclosome (APC/C), an E3 ubiquitin ligase that targets several proteins for proteolytic degradation, including mitotic cyclins [13].”