Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

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Cellular mechanisms of cadmium-induced toxicity: a review (2014, background): “Traditionally, ERK is generally considered a cell proliferation pathway with an ability to protect cells against apoptosis (Santos et al. 2007; Martin et al. 2009).”
TOXICITY TESTING IN THE 21ST CENTURY: A VISION AND A STRATEGY (2010, background): “Widely varied mathematical models of the MAPK pathway have led to novel insights and predictions as to how it functions (Orton et al., 2005; Santos et al., 2007).”
Encoding and Decoding Cellular Information through Signaling Dynamics (2013, positive): “There is also evidence for positive feedback on ERK activation through PKC (Santos et al., 2007).”
Feedback regulation of EGFR signalling: decision making by early and delayed loops (2011, methodology): “Using PC-12 cells to validate mathematical modelling, it was shown that stimulation of ERK by NGF activates the upstream kinase RAF to cause positive feedback, whereas ERK activation by EGF inhibits RAF through a negative feedback loop that results in transient ERK signallin”