Comorbidities of epilepsy: current concepts and future perspectives.
By M. Keezer, Sanjay M. Sisodiya, Josemir W Sander. Lancet Neurology, 2016
660 citations recorded by the source corpus.
The burden of comorbidity in people with epilepsy is high. Several diseases, including depression, anxiety, dementia, migraine, heart disease, peptic ulcers, and arthritis are up to eight times more common in people with epilepsy than in the general population. Several mechanisms explain how epilepsy and comorbidities are associated, including shared risk factors and bidirectional relations. There is a pressing need for new and validated screening instruments and guidelines to help with the early detection and treatment of comorbid conditions. Preliminary evidence suggests that some conditions, such as depression and migraine, negatively affect seizure outcome and quality of life. Further investigation is needed to explore these relations and the effects of targeted interventions. Future advances in the investigation of the comorbidities of epilepsy will strengthen our understanding of epilepsy and could play an important part in stratification for genetic studies.
Subfields: Genetics, Pediatrics, Perinatology and Child Health, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/916dfafec0ced6c92abe2aedf4148d33ec3f1d3e
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In Pediatrics, Perinatology and Child Health
In Psychiatry and Mental health
Citations in the corpus
- Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options (2020, background): “The known clinical risk factors for drug resistance in epilepsy also indicate that drug resistance is often associated with comorbidities that increase the overall disease burden for affected individuals; seizure control can ameliorate comorbidities and vice versa (Keezer et al., 2016).”