Polyamines and cancer: old molecules, new understanding

By E. Gerner, Frank L. Meyskens Jr. Nature Reviews. Cancer, 2004

1,090 citations recorded by the source corpus.

The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism. Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical studies. Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues.

Subfields: Biochemistry, Biotechnology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/915c20d099977165533f2c583f118451a962397b

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Citations in the corpus

Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases (2007, background): “jpg" NDATA ITEM> ]> Although simple in structure, the polycationic polyamines spermidine and spermine and their diamine precursor putrescine are essential factors for growth in eukaryotic cell”
Spermidine in health and disease (2018, background): “Given the proliferation-enhancing and cytoprotective effects of polyamines on cultured human cancer cells or xenografted human tumors evolving in immunodeficient mice [reviewed in (55)], polyamines might have procarcinogenic properties.”
Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles (2009, background): “For example, polyamines are correlated with cell growth and proliferation (Casero and Marton 2007; Gerner and Meyskens 2004; Tabor and Tabor 1984), and with tumor growth in oral cancer (Dimery et al. 1987), while putrescine is used to monitor the effect of chemotherapy on oral cancer cells (Okamura…”
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses (2016, background): “The polyamines are amino acid-derived polycationic alkylamines that are essential for the growth and survival of eukaryotic cells (22).”