Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy.

By E. Eskelinen. Molecular Aspects of Medicine, 2006

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Autophagy, amyloidogenesis and Alzheimer disease (2007, positive): “…and the Golgi complex before being engaged by either of two mannose-6-phosphate receptors (MPRs), cation-dependent 46 kDa MPR (CD-MPR) and cationindependent 215 kDa MPR (CI-MPR), which deliver them to late endosomes (LEs) (Eskelinen, 2006) before recycling to the TGN (Mullins and Bonifacino, 2001).”
Lysosomal membrane permeabilization in cell death (2008, background): “The lysosomal membrane is protected from the acidic hydrolases by lysosomespecific expression of membrane proteins such as Lamp-1 and Lamp-2, which are heavily glysosylated and hence resist digestion (Eskelinen, 2006).”
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids (2010, background): “…02139, USA 4Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan 5Howard Hughes Medical Institute 6These authors contributed equally to this work *Correspondence: sabatini@wi.mit.edu DOI 10.1016/j.cell.2010.02.024”