Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy

By I. Weinstein, Andrew K. Joe. Nature Clinical Practice Oncology, 2006

742 citations recorded by the source corpus.

Subfields: Cell Biology, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/91247e02c60a7bc3bb110a98ba4bbd2ead6abe6a

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Citations in the corpus

Mechanisms and insights into drug resistance in cancer (2013, background): “This is referred to as oncogene addiction (Arber et al., 1997; Weinstein, 2002; Weinstein and Joe, 2006; Sharma and Settleman, 2007).”
The cell cycle and cancer (2012, background): “The ‘oncogene addiction’ theory suggests a tumour will have unyielding dependence on a particular perturbation of a single gene [28].”
Transcriptional Addiction in Cancer (2017, positive): “Transcriptional addiction and cancer therapeutics The concept of oncogene addiction (Weinstein and Joe, 2006) refers to the behavior of cancer cells that exhibit an absolute dependence on oncogenes that were initially acquired during multi-step tumorigenesis and remain critical to the ongoing prolif”
Oncogene addiction. (2008, background): “We proposed that the phenomenon of oncogene addiction is a consequence of the fact that the multistage process of carcinogenesis is not simply a summation of the individual effects of activation of multiple oncogenes and inactivation of multiple tumor suppressor genes (5, 6).”
Cyclin D as a therapeutic target in cancer (2011, background): “Targeting cyclin D as therapy for cancer Oncoproteins are attractive therapeutic targets as they are causally related to cancer development, and cancer cells often become dependent on them for continued proliferation and survival ( oncogene addiction”
Integrative genomic approaches identify IKBKE as a breast cancer oncogene. (2007, background): “Together, these observations implicate IKBKE as an essential oncogene in breast cancer cell lines harboring amplifications of 1q32 and are reminiscent of similar findings made in cell lines harboring other oncogenes such as BCR-ABL and EGFR, which also appear to render oncogene-expressing cells part”