Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4.

By Hairong Peng, V. Wright, A. Usas, B. Gearhart, Hsain‐Chung Shen, J. Cummins, J. Huard. Journal of Clinical Investigation, 2002

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TSH is a negative regulator of skeletal remodeling. (2003, background): “…of p65 (and not of p50) was inhibited selec- there is evidence that VEGF can, through Flk-1 activation, synergize the actions of BMP-4 (Peng et al., 2002).tively in response to TSH. NF B, the absence of which results in osteopetrosis without osteoclasts (Iotsova et The latter effect…”
The roles of vascular endothelial growth factor in bone repair and regeneration (2016, background): “In a critical-sized defect model, musclederived stem cells in combination with overexpression of VEGF failed to heal the defect [84].”