Targeting potential drivers of COVID-19: Neutrophil extracellular traps

By B. Barnes, J. M. Adrover, Amelia Baxter-Stoltzfus, A. Borczuk, J. Cools-Lartigue, J. Crawford, J. Daßler-Plenker, P. Guerci, C. Huynh, J. Knight and 13 more. Journal of Experimental Medicine, 2020

1,357 citations recorded by the source corpus.

In this Perspective, autopsy results and literature are presented supporting the hypothesis that neutrophil extracellular traps (NETs) may contribute to organ damage and mortality in COVID-19. If correct, existing drugs that target NETs, although unspecific, may benefit COVID-19 patients.

Subfields: Immunology, Infectious Diseases, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/90c2497564232443e95a86982be76bfd6cf7f066

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Aschenbrenner
2. Oliver Stegle
3. M. Egeblad

In Infectious Diseases

1. A. Aschenbrenner
2. Richard C. Becker
3. J. Ziebuhr

Citations in the corpus

• Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment (2020, positive): “The transcriptional programs induced in immature neutrophils, including pro- and pre-neutrophils, as well as in COVID-19-associated mature neutrophil clusters, align with other observations in severe COVID-19 patients, including increased NET formation (Barnes et al., 2020; Zuo et al., 2020), coagul”
• Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome (2020, background): “Neutrophil infiltration, but without immunofluorescence testing for NETs or platelets, of this patient’s autopsy lung sample has been published.(4)”
• Immunology of COVID-19: Current State of the Science (2020, neutral): “In contrast to their early protective role, neutrophil NETosis and macrophage crosstalk can drive later-stage inflammatory cascades (Barnes et al., 2020) , underscoring the overall pathogenic nature of damagesensing host responses ( Figure 2) .”
• Neutrophil extracellular traps in COVID-19. (2020, background): “trophil effector functions in the complications of COVID-19 (67).”
• Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment (2020, background): “They also suggested that dornase alpha treatment may be beneficial for the management of this infection [31].”
• COVID-19 update: Covid-19-associated coagulopathy (2020, background): “1 3 autopsy series and developed a working hypothesis to integrate pulmonary infection, cytokines and thrombosis [20].”