In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals.

By Yong-Min Huh, Young-wook Jun, Ho-Taek Song, Sungjun Kim, Jin-sil Choi, Jae‐Hyun Lee, Sarah Yoon, Kyung-sup Kim, Jeon-Soo Shin, J. Suh and 1 more. Journal of the American Chemical Society, 2005

778 citations recorded by the source corpus.

The unique properties of magnetic nanocrystals provide them with high potential as key probes and vectors in the next generation of biomedical applications. Although superparamagnetic iron oxide nanocrystals have been extensively studied as excellent magnetic resonance imaging (MRI) probes for various cell trafficking, gene expression, and cancer diagnosis, further development of in vivo MRI applications has been very limited. Here, we describe in vivo diagnosis of cancer, utilizing a well-defined magnetic nanocrystal probe system with multiple capabilities, such as small size, strong magnetism, high biocompatibility, and the possession of active functionality for desired receptors. Our magnetic nanocrystals are conjugated to a cancer-targeting antibody, Herceptin, and subsequent utilization of these conjugates as MRI probes has been successfully demonstrated for the monitoring of in vivo selective targeting events of human cancer cells implanted in live mice. Further conjugation of these nanocrystal probes with fluorescent dye-labeled antibodies enables both in vitro and ex vivo optical detection of cancer as well as in vivo MRI, which are potentially applicable for an advanced multimodal detection system. Our study finds that high performance in vivo MR diagnosis of cancer is achievable by utilizing improved and multifunctional material properties of iron oxide nanocrystal probes.

Subfields: Biomaterials, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/90b9c2678c65b75c8ae6eb1ae8c0a6185f790172

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In Biomaterials

1. Omid Veiseh
2. J. Gunn
3. Xiaohua Huang
4. I. El-Sayed
5. M. El-Sayed
6. S. E. Achy
7. Mohamad T Houri
8. R. Bazak

In Biomedical Engineering

1. Xiaohua Huang
2. M. El-Sayed
3. I. El-Sayed
4. E. Dreaden
5. Omid Veiseh
6. J. Gunn
7. S. Sant
8. S. E. Achy

In Molecular Biology

1. Xiaohua Huang
2. M. El-Sayed
3. I. El-Sayed
4. S. Laurent
5. M. Mahmoudi
6. Miqin Zhang
7. P. Jain
8. Challa S. S. R. Kumar

Citations in the corpus

• Cancer active targeting by nanoparticles: a comprehensive review of literature (2014, background): “Trastuzumab has been conjugated to supermagnetic iron oxide nanoparticles which serve as MRI contrast agents to detect HER2-positive tumors (Huh et al. 2005; Oghabian et al. 2011).”