The voltage sensor in voltage-dependent ion channels.

By F. Bezanilla. Physiological Reviews, 2000

868 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Electrochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/90773452321994627197b27cb70f51f8aeee9cb8

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In Cellular and Molecular Neuroscience

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Citations in the corpus

hERG K(+) channels: structure, function, and clinical significance. (2012, methodology): “The process of opening and closing of voltage-dependent ion channels, in particular VGK channels, has been the subject of a plethora of studies over the past 60 years (65, 640).”
Crystal structure and mechanism of a calcium-gated potassium channel (2002, background): “In channels whose gate opens in response to the membrane voltage (voltage-dependent channels), an integral membrane ‘voltage sensor’ domain is present on each subuni”
Molecular and Cellular Biophysics: Index (2006, background): “This relation is discussed in detail by Sigworth (1994) and Bezanilla (2000).”
The open pore conformation of potassium channels (2002, background): “The mechanics of pore opening may be conserved in different K p channels, but very different structures, such as integral membrane voltage sensor”
Voltage-gated ion channels and gating modifier toxins. (2007, methodology): “This movement has been detected in fluorescent labeling experiments ( ), and the S4 voltage sensor is oriented1986 Bezanilla, 2000 across the membrane with its gating charges in an outward position in the structure of a K channel with its pore open ( ; V Long et al., 2005 ).”
The principle of gating charge movement in a voltage-dependent K+ channel (2003, background): “Conclusion Here and in an accompanying paper(4), we have shown that (1) the gating charges are carried on voltage-sensor paddles, which are helix–turn–helix structures attached to the channel through flexible S3 loops and S4–S5 linkers; (2) the paddles are located at the channel’s outer perimeter an”
X-ray structure of a voltage-dependent K+ channel (2003, background): “How does a voltage-dependent channel ‘sense’ the membrane voltage and gate open as a function of its value? It is thought that charged amino acids called ‘gating charges’ move through the membrane electric field in association with pore opening, allowing membrane voltage to bias the equilibrium betw”