Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

By M. D. Palma, M. Venneri, Cristina Roca, L. Naldini. Nature Medicine, 2003

607 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/9068c03d1850c59a7ee35bdb4e6accec2d8fc0df

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Citations in the corpus

Targeting the tumour vasculature: insights from physiological angiogenesis (2010, background): “, others found little evidence for a substantial contribution from these cell”
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system (2009, background): “Of particular interest is the expression of TIE2 by a subpopulation of monocytes that seems to primarily account for the angiogenic activity of recruited tumour-associated macrophage”
Macrophage regulation of tumor responses to anticancer therapies. (2013, background): “TAM-mediated immunosuppression is mediated, at least in part, by induction of T cell apoptosis and nitrosylation of T cell receptors via macrophage products, like ARG1, NOS2, and peroxynitrite (Gabrilovich et al., 2012). It should be noted that the study by DeNardo et al. (2011) analyzed the leukocy”
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “Recently, new evidence was provided that a distinct subset of monocytes expressing the Tie2 receptor (TEM) has a major role in tumor angiogenesis [81-83].”
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. (2011, background): “TIE2 is weakly expressed by some circulating monocytes and is significantly upregulated upon their homing to tumors and differentiation into a subset of perivascular macrophages (De Palma et al., 2003, 2005, 2008).”
Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. (2005, result): “In line with this hypothesis, the deletion of Tie-2-positive bone marrow-derived cells through activation of a suicide gene blocked tumor angiogenesis, even though in this study, cells were not found to be integrated into the endothelial lining of the tumor vessels but rather located adjacent to the”