Family-based association tests for genomewide association scans.

By Wei-Min Chen, Gonçalo R. Abecasis. American Journal of Human Genetics, 2007

426 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/90508e6389394acb42cdbde9700cac231c705db0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

Citations in the corpus

A genome-wide association study of global gene expression (2007, methodology): “We tested for association between our genotyped SNPs and expression ( Supplementary Table 1 online) using the FASTASSOC component of MERLI”
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans (2015, methodology): “g a score test mmscore [18] implemented in the GenABEL package [19]).”
Robust relationship inference in genome-wide association studies (2010, background): “…rapid computation can be applied toward automated pedigree reconstruction and association mapping in the absence of any pre-specified pedigree or population structure (Chen and Abecasis, 2007; Chen et al., 2009; Choi et al., 2009; Kang et al., 2010; Thornton and McPeek, 2010; Zhang et al., 2010).”
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing (2012, background): “Imputing into pre-phased haplotypes is known to be fast, and it is highly accurate when the haplotypes are estimated through genotyped family members 7,8 or long segments of recent shared ancestry 9 .”
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion (2009, methodology): “Analysis of FUSION FSIGT and METSIM OGTT data was carried out using a regression framework in which regression coefficients were estimated in the context of a variance component model to account for relatedness among individual”
ProbABEL package for genome-wide association analysis of imputed data (2010, methodology): “The two-step mixed model-based score test implemented in ProbABEL is an extension of the family-based association score test suggested by Chen and Abe-casis [14], and is similar in its logic to the GRAMMAR and GRAMMAR-GC tests described by Aulchenko et al. [13,15].”
Newly identified loci that influence lipid concentrations and risk of coronary artery disease (2008, methodology): “We took advantage of this relatedness to reduce genotyping costs: we genotyped 1,412 individuals with the Affymetrix 500K Mapping Array Set (organized into groups of 2–3 individuals per nuclear family) and then propagated their genotypes to the remaining individuals, who were genotyped using only th”
Identification of ten loci associated with height highlights new biological pathways in human growth (2008, methodology): “Association testing in the FUSION and SardiNIA datasets was done for both genotyped and imputed SNPs using a method that allows for relatedness, estimating regression coefficients in the context of a variance components mode”