Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

By Prakash Ramachandran, A. Pellicoro, Madeleine A. Vernon, L. Boulter, R. Aucott, Aysha Ali, S. Hartland, V. Snowdon, A. Cappon, T. Gordon-Walker and 7 more. Proceedings of the National Academy of Sciences of the United States of America, 2012

899 citations recorded by the source corpus.

Subfields: Hepatology, Immunology

View Paper: https://www.semanticscholar.org/paper/8fe6c7938818cb1f90873273b4763e8abd285c65

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hepatology

1. L. Hammerich
2. S. Friedman
3. Y. Saiman
4. J. Puche
5. F. Tacke
6. T. Baumert
7. Natascha Roehlen
8. E. Crouchet

In Immunology

1. S. Friedman
2. A. Mildner
3. L. Hammerich
4. C. Varol
5. F. Tacke
6. Steffen Jung
7. D. Brenner
8. Natascha Roehlen

Citations in the corpus

• Hepatic inflammatory responses in liver fibrosis (2023, positive): “This switch can be induced by neutrophils 95 or phagocytic stimuli 205 which lead to increased secretion of MMPs (for example, MMP9, MMP12 and MMP13) and enhanced matrix degradation 206–208 .”
• The Pathogenesis of Cardiac Fibrosis (2013, neutral): “In a model of hepatic fibrosis, Ly6Clo macrophages expressed high levels of MMPs and were suggested to play a role in regression of the fibrotic response [71, 72].”
• Liver inflammation and fibrosis. (2017, background): “Thus, the M1/M2 paradigm is probably an oversimplification for hepatic macrophages exposed to various pro- and antiinflammatory stimuli (52).”
• Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives (2020, background): “, MMP9, MMP12, MMP1), which are involved in matrix degradation and resolution of fibrosis [11,16].”
• Macrophages: development and tissue specialization. (2015, background): “It has been shown in the liver that recruited Ly6Chi monocytes differentiate into short-lived pro-restorative Ly6CloF4/80hi macrophages that outnumber the resident KC population at the early recovery phase from liver fibrosis (91) and drug-induced liver injury (88).”
• Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials (2015, background): “The proliferative phase of wound healing involves an increase in cells, the formation of new blood vessels, and the deposition of extracellular matrix [81,88,89].”