Integrons: Past, Present, and Future

By M. Gillings. Microbiology and Molecular Reviews, 2014

618 citations recorded by the source corpus.

Subfields: Endocrinology, Molecular Medicine, Pollution

View Paper: https://www.semanticscholar.org/paper/8fa8fae1f639e0f93df629023161d18c25b19e7f

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In Endocrinology

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Citations in the corpus

Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence (2019, background): “Integrons are a major source of transferable resistance determinants, both in Gram-negative and Gram-positive bacteria (Gillings 2014).”
Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens (2018, background): “…that the use of antibiotics may provide a strong selection for ‘capture’ of antibiotic resistance genes by mobile genetic elements (including plasmids, transposons, and integrons) and acting as a strong force in shaping evolution of microorganisms (Gillings, 2014; Surette and Wright, 2017).”
Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution (2014, methodology): “This integron carried a gene cassette encoding resistance to disinfectants (qacE), and subsequently captured a gene for sulphonamide resistance (sul1), deleting the terminus of the qacE cassette (Kholodii et al., 1995; Gillings et al., 2008a; Gillings, 2014a).”
Status of pathogens, antibiotic resistance genes and antibiotic residues in wastewater treatment systems (2017, background): “They are commonly distributed in Gram-negative bacteria (including pathogens) and are also present in Gram-positive bacteria (Gillings 2014).”
Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance (2020, background): “An integron is composed of a gene encoding an integrase, a specific recombination site, and a promoter that controls the expression of promoter-less genes embedded within gene cassettes [110], some of which can be located in genetic mobile elements and contain antibiotic resistancegene cassettes.”
Environmental factors influencing the development and spread of antibiotic resistance (2017, positive): “Since integrons and other mobile genetic elements allow bacteria to adapt faster to new niches (Gillings 2014), genes mobilized in the future would likely not be restricted to conferring antibiotic resistance, but may also encompass genes that provide a fitness advantage in terms of adaption to…”