Shattuck lecture--neurodegenerative diseases and prions.
By S. Prusiner. New England Journal of Medicine, 2001
728 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/8f2edb20f7437d1b7420e4bf2083d94ef05e4825
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In Cellular and Molecular Neuroscience
In Molecular Biology
- William W. Seeley
- Lary C. Walker
- Vladimir N Uversky
- Mathias Jucker
- D. Selkoe
- A. Keith Dunker
- Lukasz Kurgan
- Zsuzsanna Dosztányi
In Neurology
Citations in the corpus
- Folding proteins in fatal ways (2003, background): “These disorders are very closely related to a range of slowly progressive infectious diseases in certain lower mammals, including the defining disorder, scrapie, in shee”
- A decade and a half of protein intrinsic disorder: Biology still waits for physics (2013, background): “234, 235 An illustrative examples of human neurodegenerative diseases associated with IDPs includes Alzheimer's disease (deposition of amyloid-b, tau-protein, a-synuclein fragment NAC) [236] [237] [238] [239] ; various taupathies (accumulation of tau-protein in the form of neurofibrillary tangles) 2”
- Pathogenic Protein Seeding in Alzheimer’s Disease and Other Neurodegenerative Disorders (2011, background): “The conformationally corrupted molecules are predisposed to self-aggregation, in which state they can become injurious to neurons.(29,30) Although the mechanism of spread remains uncertain, there is evidence that prions can be conveyed between neurons by trans-synaptic transport.”
- Hallmarks of neurodegenerative diseases. (2023, neutral): “1,2,29,39,43 1–”
- Predicting regional neurodegeneration from the healthy brain functional connectome. (2012, background): “This notion, that many or all noninfectious neurodegenerative diseases may propagate along networked axons via templated conformational change, has been put forth since the introduction of the prion concept (Prusiner, 1984, 2001).”
- Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies (2002, neutral): “Protein misfolding thus is a central feature of the prion diseases (Prusiner, 2001).”