Membrane Estrogen Receptor Engagement Activates Endothelial Nitric Oxide Synthase via the PI3-Kinase–Akt Pathway in Human Endothelial Cells

By M. Haynes, Diviya Sinha, K. Russell, M. Collinge, David Fulton, M. Morales-Ruiz, W. Sessa, J. Bender. Circulation Research, 2000

599 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Physiology

View Paper: https://www.semanticscholar.org/paper/8efd74544c30953b4e379ef3c38913f7e98a9ac4

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1. L. Liu
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Citations in the corpus

• Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. (2003, unknown): “Certainly estrogen activates the estrogen receptorand increases eNOS activity by a combination of its phosphorylation on Ser1177 and its subcellular translocation (18, 52, 60, 119).”
• Nongenomic actions of steroid hormones (2003, unknown): “The PI3K–Akt pathway has been shown to be involved in this respons”
• The role of nitric oxide in cancer (2002, background): “Recently several studies have shown that the oestrogen/oestrogen receptor complex binds to the p85a regulatory subunit of phosphatidylinositol-3-OH kinase (PI-(3)K), which leads to activation of protein kinase B/Akt [26], [27].”