Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts*
By Deborah A. Brown, E. London. Journal of Biological Chemistry, 2000
2,374 citations recorded by the source corpus.
It is well known that separate domains with different lipid compositions can exist in liposomes containing mixtures of different phospholipids. The question of whether cellular membranes contain similar lipid domains has intrigued workers for many years. One type of domain, sphingolipid and cholesterol-based structures called membrane rafts, has received much attention in the last few years. We will review the evidence that rafts exist in cells and focus on their structure, or the organization of raft lipids and proteins. Our discussion of function will focus on the role of rafts in signaling in hematopoietic cells, a particularly well developed area that has provided insights into raft organization in the membrane. Several reviews of rafts (1–4) and of related structures called caveolae (5–7) have appeared recently.
Subfields: Cell Biology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/395c24cad4939684e94ecb107abbe22f24cdefad
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Citations in the corpus
- Lipid rafts: heterogeneity on the high seas. (2004, background): “Addition of cholesterol to such a mixture permits the formation of the so-called liquid-ordered phase in which saturated acyl chains are highly organized, as in thegelphase,butexhibitlateralmobilitymoresimilartothatinthe liquid crystalline phase [ 18 ,42].”
- PIP(2) and proteins: interactions, organization, and information flow. (2002, background): “to putative cholesterol-enriched rafts in the unperturbed membrane (22, 60, 95).”
- The cell biology of lysosomal storage disorders (2004, positive): “The fact that cholesterol and sphingolipid levels are inter-related in LSDs is hardly surprising because both are important components of microdomains/rafts at the cell surface 51,52 .”