Proteasomes and their kin: proteases in the machine age

By C. Pickart, R. Cohen. Nature reviews. Molecular cell biology, 2004

776 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8e6c5d27a46558fe86582cec6115c0a413cbdae6

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In Epidemiology

1. D. Finley
2. Debashish Chowdhury

In Molecular Biology

1. Debashish Chowdhury
2. D. Reinberg
3. R. Sims
4. R. Belotserkovskaya
5. D. Finley
6. Francisca E. Reyes Turcu
7. K. Wilkinson
8. Karen H. Ventii

Citations in the corpus

• A genomic and functional inventory of deubiquitinating enzymes. (2005, neutral): “The 26S proteasome consists of two 19S regulatory particles and a 20S cylinder-shaped multiprotein complex possessing the proteolytic activity (Pickart and Cohen, 2004).”
• Elongation by RNA polymerase II: the short and long of it. (2004, background): “Rtp4 and Sug1 are components of the 26S proteosome, a large cellular machine that degrades polyubiquitinated conjugated proteins (Pickart and Cohen 2004).”
• Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “and ATP-dependent complex machine for protein degradation [1447, 1448, 1449, 1450, 1451, 1452, 1453, 1454, 1455, 1456, 1457, 1458, 1459, 1460, 1461, 1462, 1463, 1465, 1466] This barrel-shaped machine has structural and functional similarities with exosome; what exosome does for RNA, proteasome does ”
• Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome (2009, background): “5 MegaDaltons, functions primarily to degrade proteins that have been modified by the attachment of the small protein ubiquitin (1, 2) (Figure 1).”
• AAA+ proteins: have engine, will work (2005, background): “Protein unfolding and degradation AAA+ proteins are crucial for proteolysis, in which their role is to unfold substrates and deliver them to the degradative chamber of so-called CHAMBERED PROTEASES”
• Regulation and Cellular Roles of Ubiquitin-specific Deubiquitinating Enzymes (2009, background): “The proteasome is a large multiprotein complex that catalyzes ubiquitin-dependent protein degradation (4, 26, 133).”
• Degradation signal diversity in the ubiquitin-proteasome system (2008, neutral): “Most regulated protein degradation in eukaryotes is executed by the ubiquitin–proteasome syste”