Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
By P. Choudary, M. Molnar, S. Evans, H. Tomita, Jun Z. Li, M. Vawter, Richard M. Myers, W. Bunney, Huda Akil, S. Watson and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2005
640 citations recorded by the source corpus.
Subfields: Biological Psychiatry, Cellular and Molecular Neuroscience
View Paper: https://www.semanticscholar.org/paper/8e54961df23dbeaed59db9f5c110b51357926f30
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biological Psychiatry
- G. Sanacora
- Bruce S. McEwen
- M. Popoli
- John H. Krystal
- G. Treccani
- Zhen Yan
- Husseini K. Manji
- K. Al-Harbi
In Cellular and Molecular Neuroscience
- G. Sanacora
- Bruce S. McEwen
- John H. Krystal
- István Módy
- Husseini K. Manji
- S. Brickley
- M. Popoli
- G. Treccani
Citations in the corpus
- Extrasynaptic GABAA receptors: Their function in the CNS and implications for disease (2012, background): “Autopsy studies from individuals who have suffered from major depression exhibit marked changes in a number of genes involved in both glutamate and GABA signaling pathways, including alterations in the expression of a5-GABAARs and d-GABAARs (Choudary et al., 2005; Sequeira et al., 2009).”
- The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission (2011, background): “Interestingly, post-mortem studies showed lower mRNA expression levels of SCL1A2 and SCL1A3 (the genes encoding the glial glutamate transporters) in the PF”
- Towards a glutamate hypothesis of depression (2011, background): “Studies demonstrating reduced expression of excitatory amino acid transporters (EAAT1, EAAT2) responsible for the majority of glutamate uptake and glutamine synthetase, the enzyme responsible for the conversion of glutamate to glutamine within glia, in several brain regions from depressed individual”
- Neurobiology of suicidal behaviour (2003, background): “The prolactin response to fenfluramine was reduced in individuals with a history of suicide attempt compared to controls and individuals without a history of suicide attempt (Corrêa et al. 2000).”
- Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders (2008, background): “Reduced expression of EAAT1 , EAAT2 and glutamine synthetase has been found in two frontal brain regions in post-mortem brain samples from individuals with MD”