β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes

By R. Robertson, J. Harmon, P. Tran, V. Poitout. 2004

797 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/8e284bcab05b89eea6b3359088020d52dbdad6d8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Tschopp
2. Rongbin Zhou
3. Greta Guarda
4. Aubry Tardivel
5. Wei Jiang
6. Zhigang Tian
7. Yiqing Yan
8. M. Birnbaum

In Surgery

1. J. Tschopp
2. M. Mbikay

Citations in the corpus

• Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review (2012, background): “Glucotoxicity and lipotoxicity are the most commonly invoked mechanisms for this failure (Robertson et al., 2004).”
• The role of FoxO in the regulation of metabolism (2008, background): “Both glucotoxicity and lipotoxicity increase the level of reactive oxygen species in beta cells (Poitout and Robertson, 2002; Robertson et al., 2004).”
• Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. (2013, background): “…are the most popular mechanisms being used to explain insulin resistance and islet b-cell dysfunction in T2D (Harding and Ron, 2002; Prentki and Nolan, 2006; Robertson et al., 2004; Weir and Bonner-Weir, 2004), although it has been difficult to determine which one is the most important.”