Depression and Hypothalamic-Pituitary-Adrenal Activation: A Quantitative Summary of Four Decades of Research

By Cinnamon A. Stetler, Gregory E. Miller. Psychosomatic Medicine, 2011

1,082 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism

View Paper: https://www.semanticscholar.org/paper/8dd36c89fdc21f4d365839c99e1ae8e38ebdcccb

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Citations in the corpus

A Unified Model of Depression (2016, positive): “Also, numerous studies have found elevated levels of cortisol in response to stress in depressed individuals (e.g., Burke, Davis, Otte, & Mohr, 2005; Knorr, Vinberg, Kessing, & Wetterslev, 2010; Stetler & Miller, 2011).”
Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving Towards a Model of Behavioral and Biological Mechanisms (2011, background): “Moreover, depression is sometimes accompanied by processes featured in our model, like chronic inflammation, excessive HPA discharge, and social difficulties (Coyne, 1976; Glassman & Miller, 2007; Howren, Lamkin, & Suls, 2009; Stetler & Miller, 2011).”
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. (2016, background): “The complex aetiology, involves dysregulated neuroendocrine (Stetler and Miller, 2011) neuroimmune (Dowlati et al., 2010), metabolic (Jokela et al., 2014) and neurotransmitter systems (Berton and Nestler, 2006).”
Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024, background): “15 Additionally, one prospective cohort study reported that a history of sleep disorders can increase the risk of depression later in life and that subjective sleep problems are associated with clinically signi ﬁ cant depressive symptoms.”
Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017, background): “It has been postulated that melancholic depression is associated with an overactive HPA axis and possibly lower inflammation due to the modulatory effects of cortisol (15, 71).”
Inflammation: depression fans the flames and feasts on the heat. (2015, background): “In addition to their effects on neural processes, cytokines promote dysregulated hypothalamic-pituitary-adrenal (HPA) axis functioning, a key characteristic of depression (25, 26).”
Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression (2013, background): “1,13 However, the effect size of d ¼ 0.59 in our study for the comparison of AUCg values in the melancholic versus atypical groups was larger than those reported by Stetler and Miller 1 for comparison of atypical versus non-atypical and melancholic versus non-melancholic ).”
Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile (2013, background): “Miller GE, Cohen S, Ritchey AK: Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model.”