A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide.

By J. Mann, Yung-yu L. Huang, M. Underwood, S. Kassir, S. Oppenheim, T. Kelly, A. Dwork, V. Arango. Archives of General Psychiatry, 2000

602 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Toxicology

View Paper: https://www.semanticscholar.org/paper/8db440042d8adf66987a0a23f4585790b3ad31ed

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Citations in the corpus

Decreased activation of lateral orbitofrontal cortex during risky choices under uncertainty is associated with disadvantageous decision-making and suicidal behavior (2010, positive): “Ventral prefrontal cortex alterations have been associated with a history of suicidal acts in post-mortem studies (Mann et al., 2000), and in structural (Aguilar et al., 2008; Monkul et al., 2007) and functional (Jollant et al., 2008) neuroimaging studies.”
Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. (2000, background): “…victims; animal models of reward, stress, and learned helplessness; and in vivo and ex vivo pharmacologic studies (Arango et al 1995, 1999; Azmitia and Gannon 1986; Blier and de Montigny 1985; Duman et al 1999; Fraser and Hensler 1990; Haddjeri et al 1998; Mann et al 2000; Petty et al 1997).”
A Research Agenda For DSM-V (2002, background): “There also seems to be strong postmortem evidence of presynaptic 5-HT dysregulation, as measured by decreases in 5-HTT binding, in the cortex of depressed subjects (Mann et al. 2000; Perry et al. 1983).”
Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “Many aspects of the 5-HT system are altered in major depression, including changes in 5-HT turnover, and receptor and transporter binding (Perry et al., 1983, Arango et al., 1995, Malison et al., 1998, Mann et al., 2000, Willeit et al., 2000, Arango et al., 2001).”
Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide (2003, background): “, 1996), a significant correlation between the polymorphism and 5-HT transporter protein expression in human postmortem tissues has not been reported (Mann et al., 2000).”
Neurobiology of suicidal behaviour (2003, background): “…binding in the prefrontal cortex of individuals with a history of suicide Psikiyatride Güncel Yaklaşımlar - Current Approaches in Psychiatry attempt and that there was an increase in imipramine binding in the hippocampus (Mann et al. 2000, Arango et al. 2001, Gross-Isseroff et al. 1989).”
Field procedures in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) (2013, methodology): “…be used in broad-based epidemiological screening (e.g. post-mortem brain studies, Arango et al., 2/mpr 279 1990; Arango et al., 2001; Arango et al., 1995; Boldrini et al., 2004; Hsiung et al., 2003; Mann et al., 2000; Mann et al., 1986; FDG-PET, Boldrini et al., 2004; Parsey et al., 2006).”