Heritability in the genomics era — concepts and misconceptions

By Peter M. Visscher, W. G. Hill, Naomi R. Wray. Nature reviews genetics, 2008

1,931 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8dad831936474c5d0f534c3449c7af884e9abe8a

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Citations in the corpus

Epigenetics as a unifying principle in the aetiology of complex traits and diseases (2010, background): “Heritability can fluctuate across different stages of life and can differ markedly in different environment”
Repeatability for Gaussian and non‐Gaussian data: a practical guide for biologists (2010, background): “…be further divided into an additive genetic and a non-additive genetic component VA and VNA, we can redefine repeatability as (Falconer & Mackay, 1996; Visscher et al., 2008): R = VA + VNA + VPE VP , (39) and the narrow-sense heritability h2 in the quantitative genetics framework as h2 = VA…”
New approaches to population stratification in genome-wide association studies (2010, background): “Mixed models Mixed models, which owe their roots to applications in animal breeding, can model population structure, family structure and cryptic relatednes”
Genome-wide association studies establish that human intelligence is highly heritable and polygenic (2011, background): “10 Intelligence is highly familial, yet the extent and nature of the genetic contribution to intelligence differences has been controversial”
Dissecting the Phenotypic Components of Crop Plant Growth and Drought Responses Based on High-Throughput Image Analysis[W][OPEN] (2014, background): “It has been speculated that the dynamic change of heritability over time for a population is a consequence of changes in the magnitude of G and E effects (Visscher et al., 2008).”
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits (2009, background): “It is clear, however, that the proportion of heritability explained by common variation for most common diseases to date is modest at best (17).”