Polyarginine enters cells more efficiently than other polycationic homopolymers.
By D. Mitchell, Lawrence Steinman, D. Kim, C. Fathman, J. Rothbard. Journal of Peptide Research, 2000
1,036 citations recorded by the source corpus.
Subfields: Microbiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8da554535b49847ea4b1fe5ee9a32c3ef4ede18f
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Citations in the corpus
- Cell‐penetrating peptides: 20 years later, where do we stand? (2013, background): “Moreover, it was demonstrated that the number of arginine residues is also crucial, with polyarginines of 7–15 residues presenting an optimal uptake [14,15].”
- A Comprehensive Model for the Cellular Uptake of Cationic Cell‐penetrating Peptides (2007, background): “Alternatively, peptides, among them oligoarginine peptides (6), were designed de novo based on structure activity relationships of PTDs.”
- Cell-penetrating peptides: design, synthesis, and applications. (2014, background): “For further reference, the reader is pointed to an in-depth model of peptide-based nanoparticle formation and internalization developed by Divita et al.72 Cellular Uptake Mechanisms of CPPs.”
- CNS Delivery Via Adsorptive Transcytosis (2008, background): “HIV Tat peptide (48–60) GRKKRRQRRRPPQ Viral transcriptional regulator (48) Syn-B1 RGGRLSYSRRRFSTSTGR Protegrin 1 (34) Syn-B3 RRLSYSRRRF Protegrin 1 (34) Homoarginine peptides ((Arg)7 and (Arg)9) RRRRRRR(RR) Synthetic (57, 118 )”