Sydney multicenter study of Parkinson's disease: Non‐L‐dopa–responsive problems dominate at 15 years

By M. Hely, J. Morris, W. Reid, Robert Trafficante. Movement Disorders, 2005

1,131 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Probing and regulating dysfunctional circuits using deep brain stimulation. (2013, neutral): “Unfortunately, with time and disease progression, the majority of PD patients develop a number of symptoms, including speech, gait, and cognitive impairment, that are largely resistant to currently available medications and DBS surgery (Hely et al., 1999, 2005).”
Evolution of cognitive dysfunction in an incident Parkinson's disease cohort. (2007, background): “Only one study has investigated the development of dementia in a newly diagnosed PD cohort followed longitudinally; 48% of surviving patients ultimately met criteria for dementia at 15 years, but annual incidence figures were not calculated (Hely et al., 2005).”
Advancing translational research with the Semantic Web (2007, background): “existing treatments [9,10], and novel or modified treatments are still being developed [11,12].”
Parkinson's disease: genetics and pathogenesis. (2011, background): “Importantly, most nonmotor symptoms show little or no response to dopamine replacement and contribute substantially to overall disability, especially late in disease (11).”