Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.

By R. Sotillo, E. Hernando, Elena Díaz-Rodríguez, J. Teruya-Feldstein, C. Cordon-Cardo, Scott W. Lowe, R. Benezra. Cancer Cell, 2007

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Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis (2009, background): “In addition, conditional overexpression of MAD2 predisposes animals to a wide range of early onset, lethal tumour”
Causes and consequences of aneuploidy in cancer (2012, background): “Depletion of RB also causes the overexpression of MAD2, a mitotic checkpoint protein whose dysregulation leads to CI”
Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008, background): “MAD2 levels are increased in Rb -deficient cells, correlating with increased levels of activating E2F, and overexpression of MAD2 is sufficient to induce aneuploidy and tumour formation in transgenic mic”
Network modeling links breast cancer susceptibility and centrosome dysfunction. (2007, background): “and in work involving transient Mad2 overexpressio”
Cell cycle, CDKs and cancer: a changing paradigm (2009, background): “Both MAD2L1-deficient and MAD2L1-overexpressing mice also develop chromosomally unstable tumour”