International Expert Committee Report on the Role of the A1C Assay in the Diagnosis of Diabetes
By D. Nathan, B. Balkau, E. Bonora, K. Borch-Johnsen, John B. Buse, S. Colagiuri, M. Davidson, Ralph DeFronzo, S. Genuth, Rury R. Holman and 11 more. Diabetes Care, 2009
2,915 citations recorded by the source corpus.
Members of the International Expert Committee have recommended that diabetes should be diagnosed if A1C is ≤6.5%, without need to measure the plasma glucose concentration (1). We are concerned that practical limitations will lead to false positives and negatives with this approach. A given A1C instrument may identify some but not other abnormal hemoglobins (http://www.ngsp.org/prog/index2.html). How, therefore, can we be sure whether a hemoglobinopathy is causing (or preventing) diagnosis? Before diagnosis, should we not also exclude iron deficiency anemia, which may increase A1C by 1–1.5%, as well as hemolytic anemia and renal failure or chronic infections, which also lower …
Subfields: Endocrinology, Diabetes and Metabolism, Genetics
View Paper: https://www.semanticscholar.org/paper/8d1f26695d11fc1ea99e2971c4b19293354161e9
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Citations in the corpus
- Creating ethnicity-specific reference intervals for lab tests from EHR data (2017, methodology): “HbA1c provides information about average blood glucose levels over the past 3 months and is associated with T2D (26).”
- Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline. (2017, positive): “It recommended classifying asymptomatic individuals as having diabetes if they had HbA1c $ 6.5% ( $ 48 mmol/mol) on 2 separate occasions and classifying asymptomatic individuals with prediabetes if they had HbA1c $ 6.0% ( $ 42 mmol/mol) (65), or HbA1c of 5.7% to , 6.5% (39 to , 48 mmol/mol) (66).”