Chemistry: Chemical con artists foil drug discovery

By J. Baell, Michael A. Walters. Nature, 2014

997 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Environmental Chemistry, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/8d1d07cdb2c910c2bbf810f80c735d6c82c6c984

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In Computational Theory and Mathematics

1. W. Jahnke
2. Stephen W. Fesik
3. Roderick E. Hubbard
4. D. Erlanson
5. H. Jhoti

Citations in the corpus

• Twenty years on: the impact of fragments on drug discovery (2016, methodology): “These include compounds identified by an NMR method called ALARM 30 , the so-called pan‑assay interference compounds (PAINS) 31–33 and known aggregators 34,35 .”
• The SARS-CoV-2 main protease as drug target (2020, neutral): “Small covalent modifiers like these may bind unspecifically, a characteristic associated with pan-assay interference compounds (PAINS).(95) Ebselen showed antiviral activity in Vero cells in the low micromolar range.”