Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

By Adam Siddiqui-Jain, C. Grand, D. Bearss, L. Hurley. Proceedings of the National Academy of Sciences of the United States of America, 2002

2,041 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8cdc77ef9de5dcbd8d33332609f555f12a190d49

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Citations in the corpus

G-quadruplexes and their regulatory roles in biology (2015, background): “The first evidence that pG4s at promoters (Figure 4A) have an effect on gene expression came from studies on the oncogene c-MYC, for which it was shown that mutations of the pG4, or the addition of a G-quadruplex stabilizing ligand affected transcription in vivo (90,91).”
G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription (2006, background): “These modes of binding are in keeping with previous results obtained with telomeric DNA (39) and with the CMYC quadruplex (17).”
Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics (2007, background): “The NMR-based G-quadruplex topologies formyc-2345 (Figure 7a) and variant myc-1245 (Figure 7b) (126), as well as the related study of the solution structure of the variant c-myc-2345 (Figure 7c) (128) G-quadruplexes correct earlier conclusions regarding proposed c-myc folding topologies based solely”
Quadruplex DNA: sequence, topology and structure (2006, background): “Subsequent studies established a relationship between quadruplex stabilization within this sequence and suppression of c-myc transcriptional activation (83), with the porphyrin TMPyP4 acting to stabilize the quadruplex structure.”
5′-UTR RNA G-quadruplexes: translation regulation and targeting (2012, background): “Subsequently, Hurley and co-workers (28) showed that mutational destabilization of the C-MYC promoter quadruplex led to a 3-fold increase in the transcription activity of a plasmid-based reporter assay.”
The Structure and Function of DNA G-Quadruplexes (2020, background): “A cocrystal structure of bos taurus DHX36 helicase bound to the MYC promoter G4 revealed a mode of binding in which the G4 makes contacts with a DHX36-specificmotif (DSM) and the C terminal OB-fold domain (Figure 4) [73].”