In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags

By X. Qian, Xiang-hong Peng, D. Ansari, Q. Yin-Goen, G. Chen, D. Shin, Lily Yang, A. Young, May D. Wang, Shuming Nie. Nature Biotechnology, 2008

1,210 citations recorded by the source corpus.

Subfields: Electronic, Optical and Magnetic Materials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8cc903af347590fdfe5e02261181c480c3950d8a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Electronic, Optical and Magnetic Materials

In Molecular Biology

Citations in the corpus

Quantum Dots and Their Multimodal Applications: A Review (2010, background): “reported that they injected small dosage of nanoparticles into subcutaneous and deep muscular sites in live animals and highly resolved SERS signals were obtained [373].”
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? (2010, positive): “…of gold nanoparticles has been studied, with the general conclusion that gold nanoparticles are able to enter cells and are trapped in vesicles, but are not able to enter the nucleus (Shukla et al. 2005; Pernodet et al. 2006; Chithrani and Chan 2007; Khan et al. 2007; Alkilany et al. 2009).”
Assessment of the Evolution of Cancer Treatment Therapies (2011, background): “[61] coupled PEGylated gold nanoparticles to a single-chain variable fragment antibody, which recognized the epidermal growth factor receptor overexpressed in many types of malignant human tumors, and demonstrated the targeting capabilities of these vectors in nude mice bearing human head-and-neck t”
X-ray scattering characterisation of nanoparticles (2015, background): “[17–21] SERS can be used for medical diagnostics [22–24] and targeting tumours.[22,23] Magnetic nanoparticles also have applications in high-density data storage,[4,5,25–28] spintronics,[4,5] and magnetic energy storage.”
Competing interests (2010, neutral): “This involves the use of immunoassay approaches for in vitro cancer diagnosis [21,22], in vivo cancer targeting and imaging [23], and”
Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy (2010, background): “Recently, Nie and co-workers showed that SERS from tumor in mice can be obtained by using the Raman reporter adsorbed onto 60 nm spherical gold nanoparticles [95].”