Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications

By Thomason Th, T. Thomas. Cellular and Molecular Life Sciences (CMLS), 2001

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Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. (2002, background): “Polyamines, including spermidine, spermine, and their precursor putrescine, have been implicated in cancer cell proliferation, protection from apoptosis, and DNA-protein binding (20).”
Polyamines: essential factors for growth and survival (2008, background): “Polyamines can also regulate cell death, particularly apoptosis (Thomas and Thomas 2001; Seiler and Raul 2005).”
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases (2015, background): “Polyamines such as spermines are multivalent cations required for cell proliferation and differentiation [43], and could help protect neurons Fig.”
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain (2009, background): “For example, polyamines interact with DNA to promote stabilization and condensation and, consequently, cell proliferation (Thomas and Thomas 2001).”
Polyamine accumulation in transgenic eggplant enhances tolerance to multiple abiotic stresses and fungal resistance (2007, background): “2006), they also play an important role in the regulation of various cellular and molecular processes including growth and development, membrane integrity, macromolecular synthesis and function (Igarashi and Kashiwagi 2000; Thomas and Thomas 2001; Kumar et al. 2006).”