Proteopathic tau seeding predicts tauopathy in vivo

By Brandon B. Holmes, J. Furman, Thomas E Mahan, T. R. Yamasaki, Hilda Mirbaha, William C. Eades, Larisa Belaygorod, Nigel J. Cairns, D. Holtzman, M. Diamond. Proceedings of the National Academy of Sciences of the United States of America, 2014

622 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/8c0d240a73922179bc6a8f720da8e335714bd253

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Ed Boyden
2. Li-Huei Tsai
3. Bradley T. Hyman
4. Anthony A. Hyman
5. A. Molliex
6. E. Mandelkow

In Neurology

1. Annabelle C. Singer
2. Ed Boyden
3. E. Mandelkow
4. Loren M. Frank

In Physiology

1. Li-Huei Tsai
2. Bradley T. Hyman
3. E. Mandelkow

Citations in the corpus

• Multi-sensory gamma stimulation ameliorates Alzheimer’s-associated pathology and improves cognition. (2019, methodology): “We performed a tau seeding assay to investigate effects of auditory GENUS on proteopathic tau propagation and observed significantly decreased average change in fluorescence resonance energy transfer (FRET) signal (STARMethods) (Holmes et al., 2014) in AC (72.”
• Tau protein liquid–liquid phase separation can initiate tau aggregation (2018, positive): “To test whether the aggregates emerging from p-tau441 droplets were on pathway with intracellular tau aggregation, we employed a cell assay for tau aggregation, in which HEK cells expressing the FTD-mutant tau repeat domain (amino acids 243 – 372 of tau441) fused to CFP or YFP, TauRDP301S-CFP/YFP, w”
• Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies (2016, background): “In contrast, larger aggregates of tau could bind heparin in the extracellular matrix and be internalized through macropinocytosis [170].”