The gut microbiome in health and in disease

By Andrew B. Shreiner, J. Kao, Vincent B. Young. Current Opinion in Gastroenterology, 2015

1,505 citations recorded by the source corpus.

Purpose of review Recent technological advancements and expanded efforts have led to a tremendous growth in the collective knowledge of the human microbiome. This review will highlight some of the important recent findings in this area of research. Recent findings Studies have described the structure and functional capacity of the bacterial microbiome in the healthy state and in a variety of disease states. Downstream analyses of the functional interactions between the host and its microbiome are starting to provide mechanistic insights into these interactions. These data are anticipated to lead to new opportunities for diagnosis, prognosis, and treatment of a variety of human diseases. Summary There is a fast growing collection of data describing the structure and functional capacity of the microbiome in a variety of conditions available to the research community for consideration and further exploration. Ongoing efforts to further characterize the functions of the microbiome and the mechanisms underlying host–microbe interactions will provide a better understanding of the role of the microbiome in health and disease.

Subfields: Food Science, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8bd8d43067a1ecb1815065b5be4d83b6f767ee7a

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Citations in the corpus

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression (2018, positive): “Both microbial dysbiosis and disrupted epithelial barrier function leading to translocation of bacteria are thought to be inducing factors in neoplastic transformation (7).”
Microbiota in health and diseases (2022, background): “Gut microbiota is considered the most significant one in maintaining our health.(4) The gut bacteria serve several functions, such as fermentation of food, protection against pathogens, stimulating immune response, and vitamin production.”
A Global Perspective on Microplastics (2020, background): “The importance of microbiomes to nutrition and disease protection is well recognized in fishes (Adamovsky et al., 2018; Llewellyn et al., 2014) and humans (Shreiner et al., 2015).”
VIBRANT: automated recovery, annotation and curation of microbial viruses, and evaluation of viral community function from genomic sequences (2020, background): “The presence of these putative dysbiosis-associated genes (DAGs) may contribute to the manifestation and/or persistence of disease, similar to what has been proposed for the bacterial microbiome [79 – 81].”
Fast automated reconstruction of genome-scale metabolic models for microbial species and communities (2018, background): “The human gut microbiome is of particular interest for metabolic modeling due to its impact on human health (54– 56).”
An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis (2016, background): “During the past decade, our understanding of the interaction between microbes and host has evolved from a passive commensal relationship to recognition that the gut microbiota is essential for maintaining immune homeostasis [5, 6].”
Multivariable association discovery in population-scale meta-omics studies (2021, background): “Human-associated microbiota has been convincingly linked to the development and progression of a wide range of complex, chronic conditions including inflammatory bowel diseases (IBD), obesity, diabetes, cancer, and cardiovascular disorders [1,2].”