Intracellular Delivery of Quantum Dots for Live Cell Labeling and Organelle Tracking

By A. M. Derfus, W. Chan, S. Bhatia. 2004

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Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, methodology): “For similar applications and as an alternative approach to the use of MRI, others have utilized QDs as probes for high resolution molecular imaging of cellular components and for tracking a cell’s activities and movements inside the body [170, 171].”
Quantum dot bioconjugates for imaging, labelling and sensing (2005, background): “Strategies to accomplish this include non-specific uptake by endocytosis, where QDs often end up in endocytic compartments ( Table 2 ); direct microinjection of nanolitre volumes, which is tedious and limits the number of cells labelled; electroporation, which uses charge to physically deliver QDs t”
Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging (2008, methodology): “have been demonstrated for intracellular delivery of inorganic quantum dots.(38) Here we demonstrate the effective use of CPdots as an extremely bright fluid phase”
An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites (2019, background): “Investigations on ligands promoting the nuclear penetration shown that nuclear location sequence (NLS) decorating NPs significantly promotes their nucleus targeting.([88]) Literature provided some other examples in that sense using NLS (CGGGPKKKRKVGG)-functionalized PLGA NPs (sizing about 72 nm) and”