Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

By C. Lagier-Tourenne, M. Polymenidou, Kasey R. Hutt, Anthony Q. Vu, Michael W. Baughn, Stephanie C. Huelga, Kevin M. Clutario, Shuo-Chien Ling, Tiffany Y. Liang, C. Mazur and 11 more. Nature Neuroscience, 2012

747 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/8a955b3c112079a8512a3460058dbfec5c1559c0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

In Neurology

Citations in the corpus

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis (2019, neutral): “Two ALS-associated mutations in TDP-43, Q331K, and M337V, have also been shown to alter mRNA splicing processes in a transgenic mice model (Polymenidou et al., 2011, 2012; Lagier-Tourenne et al., 2012; Arnold et al., 2013).”
Stress granules as crucibles of ALS pathogenesis (2013, positive): “Because TDP-43 and FUS regulate the splicing of myriad mRNAs with large introns that are critical for neuronal viability (Polymenidou et al., 2011; Colombrita et al., 2012; Lagier-Tourenne et al., 2012), it seems probable that sequestration of these mRNAs might be particularly damaging for specific ”
Axonal transport of TDP-43 mRNA granules in neurons is impaired by ALS-causing mutations (2014, positive): “Many of the mRNA targets of TDP-43 encode proteins that function in this compartment but only a subset show differential splicing with altered TDP-43 levels or TDP-43 mutations (Lagier-Tourenne et al., 2012; Polymenidou et al., 2011).”
A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation (2015, neutral): “…2012], Mbnl [Charizanis et al. 2012], Nova [Zhang et al. 2010], Ptbp2 [Licatalosi et al. 2012], Rbfox [Weyn-Vanhentenryck et al. 2014], and Tdp43 [Lagier-Tourenne et al. 2012]), and the analysis pipeline was described previously (Moore et al. 2014). m6A-CLIP/IP located the majority of m6A in the…”
Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis (2013, positive): “Similarly, FUS/TLS binds to the mRNAs encoding optineurin (Lagier-Tourenne et al., 2012; Colombrita et al., 2012), ubiquilin-2 (Lagier-Tourenne et al., 2012; Hoell et al., 2011), VAPB (Lagier-Tourenne et al., 2012; Hoell et al., 2011), and VCP (Lagier-Tourenne et al., 2012; Colombrita et al., 2012;…”