DNA repair, genome stability and cancer: a historical perspective

By P. Jeggo, L. Pearl, A. Carr. Nature Reviews. Cancer, 2015

682 citations recorded by the source corpus.

The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy.

Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/8a470b47685707dea129bf8cd15b8fe29473ecd1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Hui Shen
2. G. Way
3. Casey S. Greene
4. Peter W. Laird
5. Mostafa Karimi
6. John N. Weinstein
7. Yang Shen
8. Ilya Shmulevich

In Oncology

1. John N. Weinstein
2. Peter W. Laird

In Pathology and Forensic Medicine

1. John N. Weinstein
2. Peter W. Laird

Citations in the corpus

• Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas (2018, positive): “Loss of DDR function, conversely, is an important determinant of cancer risk, progression, and therapeutic response (Jeggo et al., 2016).”