Homeostatic Regulation of the Immune System by Receptor Tyrosine Kinases of the Tyro 3 Family

By Qingxian Lu, G. Lemke. Science, 2001

727 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/89bb0cef60d1adac3a0524a02721b64037059d9c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Karin
2. T. Lawrence
3. V. Nizet
4. Katsumori Segawa
5. S. Nagata
6. C. Rothlin
7. G. Lemke
8. N. Perkins

In Physiology

1. Katsumori Segawa
2. M. Karin
3. S. Nagata

Citations in the corpus

• Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase (2002, background): “These animals develop apparently higher levels of autoantibodies to DNA than c-mer single knockouts, together with other autoantibody specificities (23).”
• TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. (2008, background): “Tyro‐3 is most abundantly expressed in the nervous system, and is also found in ovary, testis, breast, lung, kidney, osteoclasts, and retina as well as a number of hematopoietic cell lines including monocytes/macrophages and platelets (Angelillo‐ Scherrer et al., 2001; Katagiri et al., 2001; Lai et ”
• An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. (2015, background): “Furthermore, MerTK-deficient mice develop a lupus-like autoimmune disease, and knocking out additional TAM receptor genes exaggerates this phenotype [60], suggesting that macrophages and immature dendritic cells might use the three TAM receptors differently.”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “Related to Mer TK are Axl and Tyro3, and a compound deficiency of all three receptors results in spontaneous hyperactivation of macrophages and DC and systemic autoimmunity (Lu and Lemke, 2001).”
• TAM receptors are pleiotropic inhibitors of the innate immune response. (2007, background): “Thus, we were unable to detect any secretion of IFNa or IL-12 in STAT1 / DCs in response to LPS or CpG (data not shown).”