The Challenge of Finding a Cure for HIV Infection

By D. Richman, D. Margolis, M. Delaney, W. Greene, D. Hazuda, R. Pomerantz. Science, 2009

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Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo (2010, neutral): “, and even successful adherence to the therapy does not eradicate the virus, and a rapid rebound in HIV-1 levels can occur if therapy is discontinue”
Stimulation of HIV-1-specific cytolytic T-lymphocytes facilitates elimination of latent viral reservoir after virus reactivation (2012, neutral): “More recent studies have focused on identifying small molecules that reactivate latent virus without inducing host cell activation (Richman et al., 2009).”
Origins of HIV and the AIDS pandemic. (2011, background): “Although antiretroviral treatment has reduced the toll of AIDS- related deaths, access to therapy is not universal, and the prospects of curative treatments and an effective vaccine are uncertain (Barouch 2008; Richman et al. 2009).”
Replication-competent non-induced proviruses in the latent reservoir increase barrier to HIV-1 cure (2013, background): “A major approach to eradicating HIV-1 involves reversing latency in patients on ART (Richman et al., 2009; Deeks, 2012).”