Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.

By David C. Evans, A. Watt, D. Nicoll-Griffith, T. Baillie. Chemical Research in Toxicology, 2004

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Elucidating mechanisms of drug-induced toxicity (2005, background): “The idea that the covalent binding of drugs to proteins is a factor contributing to drug toxicity still has currency, and many specific examples of such effects are known toda”
Deleterious effects of reactive metabolites (2010, neutral): “Measurement of the amount of in vitro metabolism dependent covalent binding to biological tissue is possible if radiolabeled drug is available.(99) The assay provides quantitative estimates of radioactivity irreversibly bound to tissue but does not correctly provide information about the nature of c”