Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients.

By Y. Gillet, B. Issartel, P. Vanhems, J. Fournet, G. Lina, M. Bes, F. Vandenesch, Y. Piémont, N. Brousse, D. Floret and 1 more. The Lancet, 2002

1,595 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Infectious Diseases, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/8940604d8c90e3ce15b8c93c0660e5b9270a148f

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Citations in the corpus

Antibiotics and Bacterial Resistance in the 21st Century (2014, background): “Glycopeptides Telavancin (53) Dalbavancin (56), oritavancin (54), ramoplanin (57)”
Guidelines for the management of adult lower respiratory tract infections - Full version (2011, neutral): “However, CA-MRSA can also lead to severe pulmonary infections, including necrotizing and haemorrhagic pneumonia, pneumothorax, pneumopyothorax, empyema, ventilatory failure and septicaemia [60–63].”
Quorum sensing in staphylococci. (2008, background): “Accordingly, most menstrual TSS strains belong to agr group III (58), as do all of the 16 strains initially reported to cause leukocidin-induced necrotizing pneumonia (44); most of the initially encountered VISA strains belong to agr group II (106), and most exfoliatin-producing strains belong to ag”
Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe. (2010, background): “Moreover, the description of serious invasive CA-MRSA infections, such as necrotising pneumonia, is cause for concern, because these infections are associated with a lethality of up to 75% [41].”
Community-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic (2010, background): “PVL MSSA strains can cause serious infections (321, 765, 797, 851, 902), although such outbreaks appear to be relatively rare.”
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? (2006, background): “As such, the toxin is strongly associated with necrotizing pneumonia and skin and soft-tissue infections, which account for the majority of CAMRSA infections [7, 9, 11].”
Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes. (2005, background): “The production of PVL may contribute to the unique pathogenicity of CO-MRSA [7, 9, 17, 31].”
Disarming Staphylococcus aureus from destroying human cells by simultaneously neutralizing six cytotoxins with two human monoclonal antibodies (2017, background): “aureus infections, such as necrotizing pneumonia and community associated MRSA infections in otherwise healthy people.(26,27) These observations triggered interest in the other leukocidins.”
The evolution of Staphylococcus aureus. (2008, background): “The patients were immunocompetent children or young adults, and each patient had a preceding influenza-like syndrome before developing pneumonia (Gillet et al., 2002).”
Three-year surveillance of community-acquired Staphylococcus aureus infections in children. (2005, background): “The suggested role of PVL in enhancing the organism’s ability to spread rapidly or to increase severity of invasive infections is under investigation [ 27 ].”
Autoinduction and signal transduction in the regulation of staphylococcal virulence (2003, background): “…TSS strains belong to agr group III (Ji et al., 1997), as do all the 16 strains recently found to cause leucocidin-induced necrotizing pneumonia (Gillet et al., 2002); most of the recently encountered VISA strains belong to agr group II (Sakoulas et al., 2002), and most exfoliatin-producing…”