Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?

By David J. Payne. Journal of Infectious Diseases, 2006

607 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/5eff2ad9ab79ff6ab13051b7020ed43c2b99833d

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Citations in the corpus

Community-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic (2010, background): “found that the presence or absence of PVL genes in MRSA strains did not affect strain virulence in mouse models of sepsis and SSTI, and their presence did not decrease neutrophil survival in in vitro assays (963).”
Staphylococcus aureus Elaborates Leukocidin AB To Mediate Escape from within Human Neutrophils (2013, background): “Under the infection conditions tested here where USA300 is phagocytosed by PMNs and bacterial growth is evaluated, we find that a pvl mutant displays no phenotype (8); however, a lukAB FIG 5 PMN damage caused by phagocytosed USA300 via LukAB occurs from within PMNs.”
A Field Guide to Pandemic, Epidemic and Sporadic Clones of Methicillin-Resistant Staphylococcus aureus (2011, neutral): “extensively and controversially discussed [61;237-239], with”
Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis (2010, methodology): “The focus of most studies in the staphylococcal toxin field has been on g-haemolysin (Menestrina et al., 2003), PVL (Voyich et al., 2006; Labandeira-Rey et al., 2007; Brown et al., 2009; Accepted 26 November, 2010.”
Staphylococcus aureus leukocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo (2011, background): “aureus pathogenesis on the other hand have led to conflicting conclusions due in part to the toxin’s species specificity, but PVL is believed to contribute to pneumonia (Voyich et al., 2006; Labandeira-Rey et al., 2007; Diep et al., 2010; Loffler et al., 2010).”
Pathogenesis of methicillin-resistant Staphylococcus aureus infection. (2008, background): “Like USA400, USA300 is associated with virulent disease [93]; however, USA300 causes far more”
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology (2018, background): “Voyich and coworkers (590), however, were the first to directly challenge the notion”