"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

By M. Ramalho-Santos, Soonsang Yoon, Y. Matsuzaki, R. Mulligan, D. Melton. Science, 2002

1,796 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/891866af085281661f3a9da997efd74f5b4771aa

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Citations in the corpus

Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (2008, background): “The rationale is that 9 (Nanog, Oct4, Sox2, Klf4, n-Myc, c-Myc, Esrrb, Zfx, Tcfcp2l1) out of the 13 TFs we studied are known to be downregulated upon differentiation or in differentiated cell types (Ivanova et al., 2002, 2006; Ramalho-Santos et al., 2002).”
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. (2010, background): “Consistent with a role in ES cells, previous gene profiling has shown that YAP is highly expressed in human ES cells (Ramalho-Santos et al. 2002).”
Analysis of Genes and Genomes (2004, background): “Using microarrays, transcript profiling of these different types of stem cell has revealed the presence of approximately 200 genes that are expressed within different stem cells that are not expressed within differentiated cells (Ivanova et al., 2002; Ramalho-Santos et al., 2002).”
Unchain my heart: the scientific foundations of cardiac repair. (2005, background): “of “stemness” (100) yet predisposed to differentiate into lineages of the organ in which they reside.”
The Hippo signaling pathway in stem cell biology and cancer (2014, positive): “Supporting the role for YAP and TEADs in maintaining pluripotency, the high expression of YAP and TEAD2 in ESCs, neural stem cells, and hematopoietic stem cells initially placed these genes into a general ‘stemness’ transcriptional signature based on transcriptional profiling [85].”
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. (2012, methodology): “C (Oct4, Sox2, Nanog, Lin28, Fbxo15, Zfp42, Fut4, Tbx3, Esrrb, Dppa2, Utf1, Sall4, Gdf3, Grb2, Slc2a1, Fthi17, Nr6a1) (Ng and Surani, 2011; Ramalho-Santos et al., 2002).”
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation (2009, background): “Indeed, previous gene expression profiles have confirmed the expression of these critical factors in HSCs (Ivanova et al., 2002; Ramalho-Santos et al., 2002; Venezia et al., 2004).”
The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies (2008, methodology): “Independent studies by the groups of RamalhoSantos [2] and Ivanova [3] of stem cell-specific genes using the same Affymetrix platform and similar study design found a disappointing six common DEGs among from Fifth Annual MCBIOS Conference.”