Chemokines and chemokine receptors: new insights into cancer-related inflammation

By G. Lazennec, A. Richmond. Trends in Molecular Medicine, 2010

665 citations recorded by the source corpus.

Chemokines are involved in cellular interactions and tropism in situations frequently associated with inflammation. Recently, the importance of chemokines and chemokine receptors in inflammation associated with carcinogenesis has been highlighted. Increasing evidence suggests that chemokines are produced by tumor cells and also by cells of the tumor microenvironment including cancer-associated fibroblasts, mesenchymal stem cells, endothelial cells, tumor-associated macrophages and more recently tumor-associated neutrophils. In addition to having effects on tumor cell proliferation, angiogenesis and metastasis, chemokines also appear to modulate senescence and cell survival. Here, we review recent progress on the roles of chemokines and chemokine receptors in cancer-related inflammation, and we discuss the mechanisms underlying chemokine action in cancer that might facilitate the development of novel therapies in the future.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/883b8655d6f471194d5b42f6e39eb212ba2a1a5c

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In Immunology

1. J. Condeelis
2. E. Roussos
3. A. Patsialou
4. J. Pollard

In Oncology

1. J. Condeelis
2. E. Roussos
3. A. Patsialou
4. J. Pollard
5. Lisa M. Coussens

Citations in the corpus

• CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3 (2011, neutral): “Recent studies have demonstrated that tumor cells also express restricted and specific patterns of chemoreceptors (Lazennec and Richmond, 2010; Vandercappellen et al., 2008).”
• Chemotaxis in cancer (2011, background): “In addition to chemotaxis, the chemokine network can regulate processes such as tumour cell growth, angiogenesis, immune evasion, senescence, survival, invasion and metastatic progressio”
• Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, neutral): “and hydroxyl radicals [43–48].”
• International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “CXCR1 and CXCR2 may be expressed by cancer cells, leukocytes, and endothelial cells (Waugh and Wilson, 2008; Lazennec and Richmond, 2010; Sharma et al., 2010) and may promote (1) recruitment to tumors of neutrophils, which are protumorigenic in some tumor systems but antitumorigenic in others…”
• CXCL12/CXCR4/CXCR7 Chemokine Axis and Cancer Progression (2010, neutral): “[6–8].”