Cells keep a memory of their tissue origin during axolotl limb regeneration

By M. Kragl, Dunja Knapp, Eugen Nacu, Shahryar Khattak, M. Maden, H. Epperlein, E. Tanaka. Nature, 2009

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A tissue-mapped axolotl de novo transcriptome enables identification of limb regeneration factors (2017, positive): “…following amputation, individual tissues within the limb, including skeletal muscle, cartilage, bone, and blood vessels, may contribute activated progenitor cells to the regenerating limb (Kragl et al., 2009; Muneoka et al., 1986; Sandoval-Guzmán et al., 2014); reviewed in Knapp and Tanaka, 2012).”
Deep Proteomics of the Xenopus laevis Egg using an mRNA-derived Reference Database (2014, neutral): “However, many of the most interesting biological problems are best studied in nonstandard organisms: limb regeneration in axolotl [4], red blood cell development in ice fish [5], or craniofacial developmental disorders in Darwin’s finches [6].”
A Novel Validation Algorithm Allows for Automated Cell Tracking and the Extraction of Biologically Meaningful Parameters (2011, background): “in complex multi-cellular processes, such as regeneration [4] and ontogenesis [5,6].”
On Having No Head: Cognition throughout Biological Systems (2016, background): “More recent efforts include the notion of memory for position during regeneration (Chang et al., 2002; Kragl et al., 2009; Wang et al., 2009) and development (Beloussov, 1997) and for signaling hysteresis during development (Balaskas et al., 2012), excitable cortex memory models of pseudopod…”