Human immune system variation
By Petter Brodin, Mark M. Davis. Nature reviews. Immunology, 2016
614 citations recorded by the source corpus.
The human immune system is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled systems immunology analyses, which reveal the composition of immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's immune system is now becoming clearer. Human immune systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation. Understanding when and how such influences shape the human immune system is key for defining metrics of immunological health and understanding the risk of immune-mediated and infectious diseases.
Subfields: Genetics, Immunology
View Paper: https://www.semanticscholar.org/paper/87f57d209ce57825ea78a247743188bfebf110db
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Axel Olin
- E. Henckel
- Yang Chen
- T. Lakshmikanth
- Christian Pou
- J. Mikeš
- A. Gustafsson
- A. Bernhardsson
Citations in the corpus
- Stereotypic Immune System Development in Newborn Children (2018, background): “By such systems-level analyses, coordinated changes between cells and proteins also can be appreciated and regulatory principles inferred (Kaczorowski et al., 2017; Brodin and Davis, 2017).”